UroToday.com- Frailty in the geriatric field is defined as >3 of the following; unintentional weight loss >10 pounds in the past year, weakness measured by grip strength, slow walking speed, self-reported exhaustion, and low physical activity. Many of these toxicities occur in men receiving androgen-deprivation therapy (ADT) for prostate cancer (CaP). In addition, biomarkers such as c-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor- are evidence of frailty. [click link for full article]